Imipramine hydrochloride is a original tricyclic antidepressant, a member of the dibenzazepine group of compounds. The mechanism of action of Pramin is not definitely known. However, it does not act primarily by stimulation of the central nervous system. The mode of action of the drug in controlling childhood enuresis is thought to be apart from its antidepressant effect.
Indications:
Depressive illness, nocturnal enuresis in children.
Side Effects:
The most frequent of side effects are dry mouth, constipation, urinary retention, increased heart rate, sedation, irritability, dizziness, and decreased coordination, dry mouth, increases and decreases in blood pressure and heart rate. Heart attacks, congestive heart failure, and strokes have been reported.
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Precautions:
Imipramine should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma. The sedative effect is increased when imipramine is taken with other central nervous system depressants, such as alcoholic beverages, sleeping medications, other sedatives, or antihistamines. It may increase heart rate and stress on the heart,dangerous for people with cardiovascular disease.
Contraindications:
Imipramine should not be given in conjunction with, or within 14 days of treatment with a MAO inhibitor. Combined therapy of this type could lead to the appearance of serious interactions such as hypertensive crises, hyperactivity, hyperpyrexia, spasticity, severe convulsions or coma and death may occur. Imipramine is contraindicated in patients who have shown hypersensitivity to the drug or hypersensitivity to tricyclic antidepressants belonging to the dibenzazepine group.
Use in Pregnancy and Lactation:
Pregnancy category D. Limited data suggest that imipramine is likely to be excreted in human breast milk. Known risk of damage to fetus.
Over Dosage:
Children have been reported to be more sensitive than adults to an acute overdosage of imipramine. An acute overdose in infants or young children must be considered serious and potentially fatal.
