pH of Pharmaceutical Systems
The pH of body fluids ranges between 1 and approximately 8. The stomach is the most acidic region of the body with a pH that varies between 1 and 3. The normal pH of
Pharmacotherapeutics
How Are Drugs Used Clinically in Patients? The study of the therapeutic
Absolute and Relative Bioavailability Definitions
Absolute Bioavailability The absolute bioavailability of a given drug from a dosage
Buffered Solutions & Buffer Capacity
A buffered solution is one that resists changes in its pH when small amounts of acid or base are added,
Bioequivalence
An extension of the concept of relative bioavailability, which essentially involves comparing the total amounts of a particular drug that
Bioavailability
Bioavailability means the rate and extent to which the active ingredient or active moiety is absorbed from a drug product
Bioequivalence Requirement and Bioequivalent Drug Products
Bioequivalence Requirement A requirement imposed by the FDA for in-vitro and/or in-vivo testing of specified drug products, which must be
Single/ Multi Source Drug Product
A multisource drug product is a drug product that contains the same active drug substance in the same dosage form
Pharmacophore
The pharmacophore describes the features of the molecule that interact with the target protein or receptor; a change in this